Pycnogenol® 200 mg – blood vessel protection confirmed by research
Pycnogenol® is a patented extract from the bark of the French maritime pine (Pinus pinaster), standardized for its content of oligomeric proanthocyanidins (OPCs). It is one of the most thoroughly researched plant ingredients in the world – there are over 160 clinical studies and 420 scientific publications confirming its properties.
How does Pycnogenol® support your heart and vessels?
Vascular endothelial protection
The endothelium is the inner layer of blood vessels, which plays a crucial role in controlling blood flow and pressure. Pycnogenol® protects endothelial cells from damage caused by free radicals and supports the production of nitric oxide (NO) – a substance that dilates blood vessels and improves blood flow.
A study published in “Clinical and Applied Thrombosis/Hemostasis” showed that Pycnogenol® supplementation for 8 weeks significantly improves endothelial function in individuals with elevated cardiovascular risk.
Reduction of oxidative stress
Proanthocyanidins contained in Pycnogenol® are among the strongest natural antioxidants – they are 50 times more powerful than vitamin E and 20 times more powerful than vitamin C. They neutralize free radicals that damage blood vessel cells and contribute to the development of atherosclerosis.
Support for vessel elasticity
With age, blood vessels lose elasticity, becoming stiff and less efficient. Pycnogenol® supports the synthesis of collagen and elastin – structural proteins that give vessels their flexibility. As a result, vessels adapt better to pressure changes and transport blood more effectively.
Impact on platelet aggregation
Studies have shown that Pycnogenol® can support proper blood fluidity through a mild effect on platelet aggregation. This is particularly important for individuals who spend long hours in a sitting position or travel by plane.
Ubiquinol CoQ10+ 300 mg – energy security for the heart
Coenzyme Q10 occurs in the body in two forms: ubiquinone (oxidized) and ubiquinol (reduced). Ubiquinol is the active form that directly participates in energy production in the mitochondria. Moreover, it is Ubiquinol that acts as an antioxidant, protecting cells from damage.
The problem is that with age – especially after the age of 40 – the body’s ability to convert ubiquinone into ubiquinol significantly decreases. Therefore, direct supplementation with ubiquinol is much more effective, especially for mature individuals.
How does Ubiquinol support heart function?
Energy production in heart cells
The heart is the organ with the highest energy demand in the entire body. Heart muscle cells contain the most mitochondria – small “cellular power plants” that produce ATP (adenosine triphosphate) – the universal cellular fuel. Ubiquinol is an essential component of the mitochondrial respiratory chain – without it, energy production is impossible.
A study published in “BioFactors” showed that ubiquinol supplementation for 12 weeks significantly improved left ventricular function in patients with heart failure.
Antioxidant protection
Ubiquinol is one of the strongest fat-soluble antioxidants. It protects cell membranes, mitochondria, and lipoproteins (including LDL) from oxidation. Oxidized LDL is a major factor in the development of atherosclerosis – a process that leads to narrowing of the vessels and cardiovascular diseases.
Blood pressure support
A meta-analysis of 17 clinical trials published in the “Journal of Human Hypertension” showed that coenzyme Q10 supplementation can support the maintenance of healthy blood pressure. The 300 mg dose of ubiquinol in Endogenic Cardio Prime is comparable to the doses used in clinical studies.
Regeneration of other antioxidants
Ubiquinol has a unique property – it can regenerate other antioxidants, such as vitamin E and vitamin C, restoring their activity after they have neutralized free radicals. This creates a synergistic antioxidant protection system in the body.
Propionyl-L-Carnitine HCl 1200 mg – improved heart performance
Propionyl-L-Carnitine is an advanced form of L-carnitine that combines an L-carnitine molecule with a propionyl group. This chemical modification gives the substance a special affinity for heart and muscle tissues and exhibits additional properties in supporting blood vessel function.
Impact on the cardiovascular system
Transport of fatty acids to mitochondria
The heart derives about 70% of its energy from the oxidation of fatty acids. L-carnitine is essential for transporting long-chain fatty acids across the mitochondrial membrane, where they are burned to produce ATP. Without adequate levels of carnitine, the heart cannot effectively use fats as fuel.
Improvement of blood flow in peripheral vessels
Clinical studies have shown that Propionyl-L-Carnitine can support blood flow in the lower limbs. This mechanism is related to supporting nitric oxide (NO) production in the vascular endothelium and improving oxygen utilization by the muscles.
A study published in “Cardiovascular Drugs and Therapy” showed that supplementation with Propionyl-L-Carnitine for 6 months significantly improved walking distance in individuals with intermittent claudication (leg pain during walking caused by ischemia).
Support for physical performance
Propionyl-L-Carnitine supports aerobic performance by improving oxygen utilization by muscles and optimizing energy metabolism. This is particularly important for physically active individuals and those who want to maintain good cardiovascular fitness.
Antioxidant action
Propionyl-L-Carnitine exhibits antioxidant properties, protecting cells from damage caused by free radicals generated during intense physical exercise or in ischemic conditions.
1200 mg dose – why is it important?
Clinical studies have used Propionyl-L-Carnitine doses in the range of 1000-2000 mg per day. The 1200 mg dose contained in Endogenic Cardio Prime falls within this therapeutic range, providing real support for the cardiovascular system.
Pterostilbene 200 mg – protection at the genetic level
Pterostilbene is a natural compound from the stilbene group, structurally similar to resveratrol but with significantly better bioavailability. It occurs naturally in blueberries, where it serves a protective function against pathogens. In the human body, Pterostilbene acts as a powerful antioxidant and modulator of gene expression.
Why is Pterostilbene better than resveratrol?
Pterostilbene has two methoxy groups in its structure (resveratrol has hydroxy groups), which makes it:
- Better absorbed – the bioavailability of Pterostilbene is about 4 times higher than that of resveratrol
- Active longer – the half-life in the body is significantly longer
- More lipophilic – it penetrates cell membranes more easily
How does Pterostilbene support heart and vascular health?
Activation of longevity pathways
Pterostilbene activates sirtuins – a family of proteins called “longevity genes” that regulate cellular metabolism, DNA repair, and stress resistance. Particularly important is the activation of SIRT1, which supports mitochondrial health and protects against aging processes.
Support for the lipid profile
Studies have shown that Pterostilbene can support the maintenance of healthy cholesterol and triglyceride levels in the blood. This mechanism is related to the activation of PPAR-alpha receptors, which regulate lipid metabolism.
A clinical study published in the “Journal of Agricultural and Food Chemistry” showed that Pterostilbene supplementation for 6-8 weeks had a beneficial effect on lipid parameters in individuals with elevated cholesterol.
Neurological protection
While Endogenic Cardio Prime is concentrated on heart health, it is worth mentioning that Pterostilbene also exhibits neuroprotective properties. It protects nerve cells from oxidative stress and supports cognitive functions – which is particularly important given the link between cardiovascular health and brain function.
Anti-inflammatory action
Pterostilbene modulates the activity of the transcription factor NF-κB, which controls the inflammatory response in the body. Chronic, low-level inflammation is one of the key factors in the development of cardiovascular diseases.
200 mg dose – unique on the market
Most supplements contain Pterostilbene in doses of 50-100 mg. Endogenic Cardio Prime delivers as much as 200 mg – a dose comparable to that used in clinical studies, making this product unique on the market.
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