€ 95.00
Endogenic TB-500+BPC-157 is a set of two high-purity synthetic peptides, placed in a carrier solution inside a PEN-type applicator. This product allows for precise dosing of microliter amounts of the substance, which is key in conducting experiments on cell lines or in physicochemical studies. The combination of the BPC-157 peptide and TB-500 (a fragment of thymosin beta-4) in a single research medium allows for the analysis of their potential molecular interactions and their impact on tissue cultures under controlled conditions.
TB-500 and BPC-157 are two peptides that have gained significant attention in the scientific community due to their potential activity in the context of research on tissue regeneration, angiogenesis, and modulation of cellular response. It must be clearly emphasized that all information presented in this document refers exclusively to research applications and does not constitute any therapeutic recommendations.
INTENDED FOR RESEARCH PURPOSES!
All the above-mentioned properties are observed in laboratory studies, not conducted on humans, and are for informational purposes only. Any information contained in the descriptions has not been approved by GIS, GIF, or EFSA. The substance is not a medicine, food product, or dietary supplement; consequently, it is not suitable for human consumption. The product qualifies as a chemical reagent / reference material authorized for marketing within the EU. It may be used exclusively for scientific research. Other information regarding the agent is contained in the chemical safety data sheet, which we make available for review. Products are available only to institutions or individuals associated with research or laboratory activities.
Endogenic TB-500+BPC-157 10mg+10mg PEN is a preparation in a convenient pen form containing:
Each pen contains 10 mg of TB-500 and 10 mg of BPC-157 in a stable aqueous formulation prepared using pharmaceutical technologies ensuring high purity and stability of the peptide molecules.
TB-500 is a synthetic form of a fragment of the Thymosin Beta-4 protein, a naturally occurring peptide in mammalian organisms. Its amino acid sequence comprises 43 amino acids:
Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
Physicochemical properties:
TB-500 exhibits a characteristic ability to bind actin – a structural protein of the cellular cytoskeleton – through the actin-binding domain located in its N-terminal part.
BPC-157 is a pentadecapeptide consisting of 15 amino acids derived from a fragment of a gastric protective protein.
Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Physicochemical properties:
BPC-157 is characterized by a unique spatial structure that enables its interaction with numerous cellular receptors and growth factors.
Below are the molecular mechanisms of TB-500 and BPC-157 observed in in vitro and in vivo studies on animal models. This information is strictly scientific and does not constitute any therapeutic indications.
TB-500 binds monomeric G-actin (globular actin) and prevents its polymerization into F-actin (filamentous) form. This process has a significant impact on cellular cytoskeleton dynamics, which in in vitro studies has shown influence on:
Activation of Signaling Cascades
Studies have shown that TB-500 can activate Integrin-Linked Kinase (ILK), leading to the activation of signaling pathways:
Stimulation of Angiogenesis
In in vitro models, it has been observed that TB-500 can stimulate endothelial cell differentiation and the formation of vascular structures through:
Modulation of Inflammatory Response
TB-500 exhibits an influence on the modulation of pro-inflammatory cytokine release (TNF-α, IL-6) and the stimulation of anti-inflammatory cytokines (IL-10) in in vitro studies.
Regulating Angiogenesis
BPC-157 in in vitro studies has shown influence on the angiogenesis process through:
This process was observed in cell cultures of the HUVEC (Human Umbilical Vein Endothelial Cells) line.
Nitric Oxide (NO) Stabilization
BPC-157 affects the synthesis and stability of nitric oxide by regulating nitric oxide synthase (NOS) activity. Studies have shown both activation and stabilization of NOS depending on the research model.
Modulation of Growth Factors
In studies on animal models, it has been observed that BPC-157 can modulate the expression of:
Cytoprotective Action
In cell cultures, it has been demonstrated that BPC-157 can protect cells from oxidative damage and influence the integrity of the mucosal barrier by regulating tight junction proteins.
Modulation of JAK/STAT and MAPK Pathways
BPC-157 in in vitro studies has shown the ability to influence the JAK/STAT and MAPK signaling pathways, which are crucial for cellular proliferation and differentiation processes.
Endogenic TB-500+BPC-157 10mg+10mg PEN can be utilized in a variety of in vitro and in vivo research projects on animal models. Below are examples of research areas:
Both peptides exhibit proangiogenic activity in in vitro studies, making them valuable tools for:
In animal models, TB-500 and BPC-157 are used for research on:
These peptides can be applied in research on:
TB-500, due to its actin-binding capability, is used in studies on:
BPC-157 finds application in research on:
These peptides can be used as reference substances in pharmacological studies concerning:
Endogenic TB-500+BPC-157 10mg+10mg PEN is a specialized preparation intended exclusively for research applications under controlled laboratory conditions. The product is not a medicinal product, dietary supplement, or cosmetic, and must not be used in humans.
Key Product Features:
Important Disclaimers:
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