Oxymedin
Oxymedin
285,99 €
191-Amino Acids
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191-Amino Acids — research reagents of the GH/IGF-1 axis: Oxytropin (somatropin rhGH) and Oxymedin (IGF-1 LR3), RUO
The Oxy line covers two reagents representing two links in the same hormonal axis. Oxytropin is somatropin (rhGH) — recombinant human growth hormone, a protein of 191 amino acid residues obtained by recombinant DNA technology. Oxymedin is IGF-1 LR3 (Long R3 IGF-1) — an 83-amino-acid analogue of insulin-like growth factor, with reduced affinity for the IGF-binding proteins (IGFBPs) and prolonged action, signalling through the IGF-1R receptor. In their reagent versions, both serve as research materials for work on this axis, not as therapeutic preparations.
The category name refers to the 191-amino-acid sequence of somatropin. Oxymedin is not a 191-amino-acid protein; it is grouped here because it is the main peripheral effector of the same GH/IGF-1 axis.
The GH/IGF-1 axis links the growth hormone secreted by the pituitary with the insulin-like growth factor produced mainly in the liver: GH (the upper link) stimulates the production of IGF-1 (the main peripheral effector). It is one of the central systems regulating protein, fat and carbohydrate metabolism in experimental models. Materials in this category remain reagents — they serve to observe that signalling under laboratory conditions, not to treat anything.
What you will find in this category
The category collects somatropin (Oxytropin) in two preparation variants and the IGF-1 LR3 analogue (Oxymedin) as a single vial and a two-pack.
Products in this category
- Oxytropin — the somatropin lyophilisate alone (100 IU per vial), with no solvent included; the researcher selects the solvent.
- Oxytropin with bacteriostatic water — the somatropin lyophilisate supplied together with bacteriostatic water for reconstitution.
- Oxymedin — IGF-1 LR3 (Long R3 IGF-1), an insulin-like growth factor analogue acting through the IGF-1R receptor.
- Oxymedin (IGF-1 LR3), 2 pieces — the same reagent in a pack of two.
Related materials
- Oxytropin 60 IU PEN — somatropin as a factory-prepared solution in a pen applicator; listed in the pens category.
- Peptides that increase growth hormone — the neighbouring category of secretagogues of the upper link in the axis (GH).
- Bacteriostatic water 10 ml — solvent for reconstituting protein lyophilisates.
REGULATORY STATUS (critical)
Both links have counterparts authorised as medicines. Somatropin (Oxytropin) has the counterparts Genotropin®, Omnitrope®, Norditropin®; IGF-1 (Oxymedin — the IGF-1 LR3 analogue) has the counterpart mecasermin (Increlex®) — RUO reagents are NOT substitutes for any of these medicines, do not serve to treat GH or IGF-1 deficiency and do not replace medical consultation. Growth hormone and its releasing factors, together with growth factors (including IGF-1 and its analogues), appear on the WADA Prohibited List in section S2; the researcher verifies the current status through the ADAMS system.
Applications in scientific research
Working concentrations and the route of administration in an experimental model are chosen by the researcher — the category defines neither doses nor protocols. GH/IGF-1 axis reagents are often reference material in work on:
- the GH/IGF-1 axis and its regulation in in vitro models,
- growth hormone receptor signalling (GHR, the JAK2/STAT5 pathway) and IGF-1R receptor signalling (the PI3K/Akt/mTOR and MAPK pathways),
- protein, lipid and carbohydrate metabolism and muscle protein synthesis in cellular systems,
- comparisons of rhGH forms and preparation variants and of IGF-1 analogues for stability and identity,
- analytical methods for determining somatropin and IGF-1 (identification, purity, activity).
SCIENTIFIC PERSPECTIVE
Somatropin and IGF-1 LR3 are proteins and protein analogues — sensitive to temperature, shaking, pH and freeze–thaw cycles. The identity, purity and activity of each batch are settled by the certificate of analysis (COA), not by the trade name. The outcome of a study depends on maintaining the cold chain and on correct reconstitution.
IMPORTANT DISTINCTION
Oxytropin (somatropin rhGH) and Oxymedin (IGF-1 LR3) are two different molecules with different receptors (GHR vs IGF-1R) — the upper link in the axis and its peripheral effector, not variants of the same material. The RUO reagents remain separate from the authorised somatropin medicines and from mecasermin. Identity and activity are confirmed by the batch COA. Messaging about this category uses no therapeutic, anti-ageing or physique claims.
Forms and preparation
- Lyophilisate without water — the powder alone (Oxytropin, Oxymedin); the researcher selects and adds the solvent separately (bacteriostatic water, for example), which gives full control over the concentration of the working solution.
- Lyophilisate with bacteriostatic water — a set with the solvent included, ready for preparing a solution (Oxytropin with bacteriostatic water).
- Reconstituting the protein — the solvent is not introduced directly onto the powder but in a slow stream down the wall of the vial; the vial should not be shaken, gentle swirling until dissolved is enough; the made-up solution is kept refrigerated. Before opening, the lyophilisate is most stable at −20 °C.
Frequently asked questions (FAQ)
How does Oxytropin differ from Oxymedin?
Oxytropin is somatropin (rhGH, the 191 aa growth hormone) — the upper link in the axis. Oxymedin is IGF-1 LR3 (Long R3 IGF-1), an insulin-like growth factor analogue acting through the IGF-1R receptor — the main peripheral effector of the same axis. GH stimulates IGF-1 production, but these are two different molecules with different receptors (GHR vs IGF-1R).
Why is Oxymedin in the 191-Amino Acids category?
The category name describes somatropin, the 191-amino-acid growth hormone. Oxymedin (83 amino acids) belongs to the same GH/IGF-1 axis as its peripheral effector, which is why both reagents are grouped together. The name of the category does not describe the structure of Oxymedin.
How does IGF-1 LR3 differ from native IGF-1?
By the substitution of arginine at position 3 and a 13-amino-acid extension of the N-terminus. Both modifications lower its affinity for the IGF-binding proteins (IGFBPs), so the analogue stays available to the receptor longer and acts for longer than the native molecule.
May the materials be used in humans or animals?
No. Materials in this category carry Research Use Only status and are not intended for any in vivo application. Somatropin, IGF-1 and its analogues moreover appear on the WADA Prohibited List (S2).
What confirms the identity and activity of the material?
The certificate of analysis (COA) for the batch — a trade name does not replace analytical data on sequence, mass and purity.