Cardio Prime 60 caps

Cardio Prime 60 caps Endogenic is an advanced formula designed for comprehensive cardiovascular support. The product combines four precisely selected ingredients in robust doses that act synergistically at various levels – from protecting cells against oxidative stress, through supporting energy production in the mitochondria, to improving blood vessel elasticity.

Endogenic Cardio Prime is a dietary supplement containing four carefully selected active ingredients. Each serving (2 capsules) provides:

• Pycnogenol® 100 mg – branded maritime pine bark extract
• Ubiquinol CoQ10+ 150 mg – the active form of coenzyme Q10
• Propionyl-L-Carnitine HCl 600 mg – an advanced form of L-carnitine
• Pterostilbene 100 mg – a natural compound from the stilbene family

Why is this formula so unique?

Synergistic action of ingredients

Each ingredient in Endogenic Cardio Prime was chosen not only for its individual properties but, above all, because these four substances mutually reinforce their action. While Pycnogenol® protects blood vessels from damage, Ubiquinol provides energy for heart cells. Propionyl-L-Carnitine supports the transport of fatty acids to the mitochondria, and Pterostilbene acts at the genetic level, activating cellular defense mechanisms.

Therapeutic, not symbolic doses

The confirmed composition of 2 Endogenic Cardio Prime capsules is: Pycnogenol® 100 mg, ubiquinol CoQ10+ 150 mg, Propionyl-L-Carnitine HCl 600 mg and Pterostilbene 100 mg. Amounts in a product serving must be distinguished from doses used in the cited clinical studies.

Bioactive forms of ingredients

The product contains Ubiquinol – the reduced form of CoQ10, which is 3-8 times better absorbed than traditional ubiquinone. This means your body can actually utilize the provided coenzyme Q10 instead of losing it during the digestion process.

See also Endogenic Meldronate

The recommended daily portion is 2 capsules, which provide:

• Pycnogenol® 100 mg
• Ubiquinol CoQ10+ 150 mg
• Propionyl-L-Carnitine HCl 600 mg
• Pterostilbene 100 mg

Best time to take

1. With a meal containing fats – Ubiquinol and Pterostilbene are lipophilic substances (fat-soluble), therefore their absorption is significantly better when taken with a meal containing healthy fats (e.g., olive oil, avocado, nuts, fatty fish).
2. Morning or midday – Due to the support of cellular energy production, it is best to take Endogenic Cardio Prime in the first half of the day. Some individuals may experience increased energy following ubiquinol supplementation.

Pycnogenol® 100 mg – blood vessel protection confirmed by research

Pycnogenol® is a patented extract from the bark of the French maritime pine (Pinus pinaster), standardized for its content of oligomeric proanthocyanidins (OPCs). It is one of the most thoroughly researched plant ingredients in the world – there are over 160 clinical studies and 420 scientific publications confirming its properties.

How does Pycnogenol® support your heart and vessels?

Vascular endothelial protection

The endothelium is the inner layer of blood vessels, which plays a crucial role in controlling blood flow and pressure. Pycnogenol® protects endothelial cells from damage caused by free radicals and supports the production of nitric oxide (NO) – a substance that dilates blood vessels and improves blood flow.

A study published in “Clinical and Applied Thrombosis/Hemostasis” showed that Pycnogenol® supplementation for 8 weeks significantly improves endothelial function in individuals with elevated cardiovascular risk.

Reduction of oxidative stress

Proanthocyanidins contained in Pycnogenol® are among the strongest natural antioxidants – they are 50 times more powerful than vitamin E and 20 times more powerful than vitamin C. They neutralize free radicals that damage blood vessel cells and contribute to the development of atherosclerosis.

Support for vessel elasticity

With age, blood vessels lose elasticity, becoming stiff and less efficient. Pycnogenol® supports the synthesis of collagen and elastin – structural proteins that give vessels their flexibility. As a result, vessels adapt better to pressure changes and transport blood more effectively.

Impact on platelet aggregation

Studies have shown that Pycnogenol® can support proper blood fluidity through a mild effect on platelet aggregation. This is particularly important for individuals who spend long hours in a sitting position or travel by plane.

Ubiquinol CoQ10+ 150 mg – energy security for the heart

Coenzyme Q10 occurs in the body in two forms: ubiquinone (oxidized) and ubiquinol (reduced). Ubiquinol is the active form that directly participates in energy production in the mitochondria. Moreover, it is Ubiquinol that acts as an antioxidant, protecting cells from damage.

The problem is that with age – especially after the age of 40 – the body’s ability to convert ubiquinone into ubiquinol significantly decreases. Therefore, direct supplementation with ubiquinol is much more effective, especially for mature individuals.

How does Ubiquinol support heart function?

Energy production in heart cells

The heart is the organ with the highest energy demand in the entire body. Heart muscle cells contain the most mitochondria – small “cellular power plants” that produce ATP (adenosine triphosphate) – the universal cellular fuel. Ubiquinol is an essential component of the mitochondrial respiratory chain – without it, energy production is impossible.

A study published in “BioFactors” showed that ubiquinol supplementation for 12 weeks significantly improved left ventricular function in patients with heart failure.

Antioxidant protection

Ubiquinol is one of the strongest fat-soluble antioxidants. It protects cell membranes, mitochondria, and lipoproteins (including LDL) from oxidation. Oxidized LDL is a major factor in the development of atherosclerosis – a process that leads to narrowing of the vessels and cardiovascular diseases.

Blood pressure support

A meta-analysis of 17 clinical trials published in the “Journal of Human Hypertension” showed that coenzyme Q10 supplementation can support the maintenance of healthy blood pressure. Two Endogenic Cardio Prime capsules contain 150 mg of ubiquinol. The amount in the product must be distinguished from doses used in clinical studies.

Regeneration of other antioxidants

Ubiquinol has a unique property – it can regenerate other antioxidants, such as vitamin E and vitamin C, restoring their activity after they have neutralized free radicals. This creates a synergistic antioxidant protection system in the body.

Propionyl-L-Carnitine HCl 600 mg – improved heart performance

Propionyl-L-Carnitine is an advanced form of L-carnitine that combines an L-carnitine molecule with a propionyl group. This chemical modification gives the substance a special affinity for heart and muscle tissues and exhibits additional properties in supporting blood vessel function.

Impact on the cardiovascular system

Transport of fatty acids to mitochondria

The heart derives about 70% of its energy from the oxidation of fatty acids. L-carnitine is essential for transporting long-chain fatty acids across the mitochondrial membrane, where they are burned to produce ATP. Without adequate levels of carnitine, the heart cannot effectively use fats as fuel.

Improvement of blood flow in peripheral vessels

Clinical studies have shown that Propionyl-L-Carnitine can support blood flow in the lower limbs. This mechanism is related to supporting nitric oxide (NO) production in the vascular endothelium and improving oxygen utilization by the muscles.

A study published in “Cardiovascular Drugs and Therapy” showed that supplementation with Propionyl-L-Carnitine for 6 months significantly improved walking distance in individuals with intermittent claudication (leg pain during walking caused by ischemia).

Support for physical performance

Propionyl-L-Carnitine supports aerobic performance by improving oxygen utilization by muscles and optimizing energy metabolism. This is particularly important for physically active individuals and those who want to maintain good cardiovascular fitness.

Antioxidant action

Propionyl-L-Carnitine exhibits antioxidant properties, protecting cells from damage caused by free radicals generated during intense physical exercise or in ischemic conditions.

600 mg per 2 capsules – comparison with research

Clinical studies have used Propionyl-L-Carnitine doses in the range of 1000-2000 mg per day. Two Endogenic Cardio Prime capsules contain 600 mg of Propionyl-L-Carnitine HCl, which is below that research range; these amounts must not be treated as equivalent.

Pterostilbene 100 mg – protection at the genetic level

Pterostilbene is a natural compound from the stilbene group, structurally similar to resveratrol but with significantly better bioavailability. It occurs naturally in blueberries, where it serves a protective function against pathogens. In the human body, Pterostilbene acts as a powerful antioxidant and modulator of gene expression.

Why is Pterostilbene better than resveratrol?

Pterostilbene has two methoxy groups in its structure (resveratrol has hydroxy groups), which makes it:

• Better absorbed – the bioavailability of Pterostilbene is about 4 times higher than that of resveratrol
• Active longer – the half-life in the body is significantly longer
• More lipophilic – it penetrates cell membranes more easily

How does Pterostilbene support heart and vascular health?

Activation of longevity pathways

Pterostilbene activates sirtuins – a family of proteins called “longevity genes” that regulate cellular metabolism, DNA repair, and stress resistance. Particularly important is the activation of SIRT1, which supports mitochondrial health and protects against aging processes.

Support for the lipid profile

Studies have shown that Pterostilbene can support the maintenance of healthy cholesterol and triglyceride levels in the blood. This mechanism is related to the activation of PPAR-alpha receptors, which regulate lipid metabolism.

A clinical study published in the “Journal of Agricultural and Food Chemistry” showed that Pterostilbene supplementation for 6-8 weeks had a beneficial effect on lipid parameters in individuals with elevated cholesterol.

Neurological protection

While Endogenic Cardio Prime is concentrated on heart health, it is worth mentioning that Pterostilbene also exhibits neuroprotective properties. It protects nerve cells from oxidative stress and supports cognitive functions – which is particularly important given the link between cardiovascular health and brain function.

Anti-inflammatory action

Pterostilbene modulates the activity of the transcription factor NF-κB, which controls the inflammatory response in the body. Chronic, low-level inflammation is one of the key factors in the development of cardiovascular diseases.

100 mg per 2 capsules

Most supplements contain Pterostilbene in doses of 50-100 mg. Two Endogenic Cardio Prime capsules provide 100 mg of Pterostilbene.

People caring for heart and vascular health

If you care about long-term cardiovascular health, Endogenic Cardio Prime provides comprehensive support on many levels:

• Protection of heart cells against oxidative stress
• Support for energy production in the mitochondria
• Improvement of elasticity and function of blood vessels
• Support for healthy blood pressure

People over 40 years of age

With age, the level of coenzyme Q10 in the body naturally decreases, vascular endothelial function deteriorates, and oxidative damage increases. Endogenic Cardio Prime provides ingredients that help counteract these processes:

• Ubiquinol compensates for the decline in endogenous CoQ10 production
• Pycnogenol® protects vessels against aging
• Pterostilbene activates cellular repair mechanisms

For the physically active

Intense physical exertion increases the heart’s demand for energy and generates additional oxidative stress. Endogenic Cardio Prime supports:

• Aerobic capacity and cellular energy
• Blood flow to working muscles
• Post-exercise recovery
• Protection against damage caused by free radicals

In case of genetic predispositions

If cardiovascular problems have occurred in your family, prevention is particularly important. Endogenic Cardio Prime is an investment in long-term health:

• Support for endothelial function
• Protection against LDL oxidation
• Support for a healthy lipid profile
• Reduction of oxidative stress

People leading a sedentary lifestyle

Long hours in a sitting position, lack of movement, and professional stress are risk factors for the cardiovascular system. Endogenic Cardio Prime helps to:

• Support blood flow in the lower limbs
• Protect vessels from the effects of inactivity
• Provide antioxidants that neutralize oxidative stress
• Support energy production in heart cells

Why is Endogenic Cardio Prime the best option on the supplement market?

High doses of active substances. While most supplements contain ingredients in doses too low to bring real benefits, Endogenic Cardio Prime provides the following amounts of ingredients per 2 capsules:

• 150 mg of ubiquinol per 2 capsules
• 100 mg of Pycnogenol® per 2 capsules
• 600 mg of Propionyl-L-Carnitine HCl per 2 capsules
• 100 mg of Pterostilbene per 2 capsules

Bioactive forms of ingredients

The product contains Ubiquinol (not ubiquinone) – the active form of CoQ10, which is significantly better absorbed. This means you are paying for ingredients that actually work in your body.

Comprehensive support on many levels

Instead of buying four separate supplements, you receive a complete formula where the ingredients mutually reinforce their action:

• Vascular protection + cellular energy + blood flow + longevity
• Antioxidants + mitochondrial support + endothelial protection
• One product = comprehensive protection

Science-based

Every ingredient in Endogenic Cardio Prime has been selected based on solid scientific research published in reputable medical journals. These are not trendy “superfoods,” but substances with proven effects.

1. Enseleit F, et al. “Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease” – European Heart Journal, 2012
2. Mortensen SA, et al. “The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO” – JACC: Heart Failure, 2014
3. Riche DM, et al. “Analysis of safety from a human clinical trial with pterostilbene” – Journal of Toxicology, 2013